Obesity is associated with development of clear cell and possibly chromophobe renal cell carcinoma (RCC), but not papillary RCC, researchers concluded.
In a nested case-control study within the Kaiser Permanente Northern California (KPNC) health care network, a team led by Mark P. Purdue, PhD, of the National Cancer Institute in Bethesda, Maryland, found that obesity (a body mass index of 30 kg/m2 or higher) was associated with significant 1.5-fold increased odds of clear cell RCC and non-significant 2.5-fold increased odds of chromophobe RCC. In a meta-analysis that included 3 additional previously published studies, Dr Purdue and his colleagues found that obesity was associated with a significant 1.8- and 2.2-fold increased summary relative risk of clear cell and chromophobe RCC, but was not significantly associated with papillary RCC.
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